![]() ![]() Rather than clustering the data first and calculating differential abundance of samples within clusters, MELD provides a density estimate for each scRNA-seq sample for every cell in each dataset. The goal of MELD is to identify populations of cells that are most affected by an experimental perturbation. Daniel B Burkhardt*, Jay S Stanley*, Alexander Tong, Ana Luisa Perdigoto, Scott A Gigante, Kevan C Herold, Guy Wolf, Antonio J Giraldez, David van Dijk, Smita Krishnaswamy. ![]() Quantifying the effect of experimental perturbations at single-cell resolution. For an in depth explanation of the algorithm, read our manuscript on BioRxiv. MELD is a Python package for quantifying the effects of experimental perturbations. MELD Quantifying the effect of experimental perturbations at single-cell resolution ![]()
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